Post by Ardbeg... innit on Jun 9, 2011 6:19:57 GMT -6
Fortunately I am on a 20mg dose. Although I have noticed rapid muscle deterioration laying on beach lounge chairs in tropical locations, its probably not related. More
Simvastatin can damage muscles in high doses
The cholesterol-lowering drug simvastatin can cause severe muscle damage and should not be prescribed in high doses to patients who have taken it for less than a year or in any dose to people taking certain drugs, health officials said Tuesday.
Simvastatin is the second-most-prescribed drug in the USA. It is sold by itself as Zocor and in combination with another cholesterol-lowering drug, ezetimibe, as Vytorin.
Last year, doctors wrote 94 million prescriptions for the two brand-name drugs, according to IMS Health, which tracks the medical marketplace. Millions more people take generic versions of the drug, says Michael Rosenblatt, chief medical officer of Merck & Co. Inc., the company that developed simvastatin.
Rosenblatt says it is crucial to alert people taking the drug to the link between simvastatin and muscle damage, which was bolstered by a Food and Drug Administration review announced last March.
Research has shown that the highest dose of simvastatin, 80 milligrams, causes muscle damage in 61 of every 1,000 patients, far higher than the eight-per-10,000 rate in patients taking a 40-milligram dose, Rosenblatt says.
About 12% of people taking Merck's simvastatin, or 1.2 million people, are taking the 80-milligram dose. "We really want to get the word out," he says.
The FDA said any patient now taking the 80-milligram dose of simvastatin who has been on it less than a year should be switched to a different cholesterol-lowering statin of equal potency. Patients taking any dose of simvastatin who are also taking certain anti-fungal drugs, antibiotics or protease inhibitors for treating HIV should also be switched to other statins.
The cholesterol-lowering drug simvastatin can cause severe muscle damage and should not be prescribed in high doses to patients who have taken it for less than a year or in any dose to people taking certain drugs, health officials said Tuesday.
Simvastatin is the second-most-prescribed drug in the USA. It is sold by itself as Zocor and in combination with another cholesterol-lowering drug, ezetimibe, as Vytorin.
Last year, doctors wrote 94 million prescriptions for the two brand-name drugs, according to IMS Health, which tracks the medical marketplace. Millions more people take generic versions of the drug, says Michael Rosenblatt, chief medical officer of Merck & Co. Inc., the company that developed simvastatin.
Rosenblatt says it is crucial to alert people taking the drug to the link between simvastatin and muscle damage, which was bolstered by a Food and Drug Administration review announced last March.
Research has shown that the highest dose of simvastatin, 80 milligrams, causes muscle damage in 61 of every 1,000 patients, far higher than the eight-per-10,000 rate in patients taking a 40-milligram dose, Rosenblatt says.
About 12% of people taking Merck's simvastatin, or 1.2 million people, are taking the 80-milligram dose. "We really want to get the word out," he says.
The FDA said any patient now taking the 80-milligram dose of simvastatin who has been on it less than a year should be switched to a different cholesterol-lowering statin of equal potency. Patients taking any dose of simvastatin who are also taking certain anti-fungal drugs, antibiotics or protease inhibitors for treating HIV should also be switched to other statins.
